空气性阴道炎与宫内皮质瘤中碳酸化酶IX相关
Švitrigailė Grincevičienė1, Daiva Vaitkienė2, Daiva Kanopienė3
1Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio Av. 7, 10257, Vilnius, Lithuania. svitrigaile.grinceviciene@bti.vu.lt.
Scientific reports
|April 16, 2024
概括
中度或重度的有氧性阴道炎 (msAV) 与高度的宫内皮质瘤 (CIN2+) 有关. 这种与msAV的关联在妇女的吸烟或伴侣数量方面都存在.
科学领域:
- 妇科 妇科医生 妇科
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 宫内皮质瘤 (CIN) 是宫癌的前体.
- 阴道微生物群的改变,如有氧性阴道炎 (AV),可能会影响宫健康.
- 碳酸无水酶IX (CAIX) 是一种低氧诱导蛋白质,与癌症进展有关.
研究的目的:
- 调查阴道微生物群,CAIX表达和CIN组织学发现之间的关联.
- 为了确定特定的阴道微生物群概况是否与宫病变的严重程度相关.
主要方法:
- 研究包括132名女性:66名高度CIN (CIN2+),14名低度CIN (CIN1) 和52名对照.
- 进行了阴道液的pH值,显微镜检查和检测感染 (克拉米迪亚虫,Trichomonas vaginalis).
- 从结肠镜检查的活检被分析为CIN,并且化样本被免疫染色为CAIX.
主要成果:
- 细菌性阴道炎 (BV) 的患病率在不同组中相似.
- 中度或重度有氧性阴道炎 (msAV) 在CIN2+ (53.0%) 病例中比CIN1 (21.4%) 病例更为频繁.
- 中度或强度的CAIX免疫染 (msCAIX) 在CIN1.1中不存在. 在CAIX未染色的CIN2患者中,msAV的流行率高 (p=0.049). 在CIN3.3中观察到msAV和msCAIX的同位点.
结论:
- 中度或重度的有氧性阴道炎与高度的宫内皮质瘤有关.
- msAV与高度CIN之间的关联与吸烟和性伴侣数量无关.
- 在CIN病变中,CAIX表达模式可能与特定的阴道微生物群状态相关.
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