抗生素相关脑病变的发生率和预测因素:一项多中心医院研究
Jean Hee Kim1, Taewon Kim2, Woojun Kim3
1Department of Neurology, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
Scientific reports
|April 16, 2024
概括
与抗生素相关的脑病变 (AAE) 在某些抗生素类别和组合疗法中更常见. 降低功能和特定的EEG模式增加了AAE风险,突显了需要仔细选择抗生素的需要.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 抗生素相关脑病变 (AAE) 是使用抗生素的严重不良影响.
- 了解AAE的风险因素和模式对于患者安全至关重要.
- 以前的研究表明,与不同类型的抗生素相关的风险不同.
研究的目的:
- 评估抗生素相关脑病变 (AAE) 的发生率和可能性.
- 为了比较单独治疗和组合治疗中使用的不同类型抗生素之间的AAE率.
- 为了研究AAE与膜过率 (GFR) 和脑电图 (EEG) 特征的关联.
主要方法:
- 六家医院对97,433例涉及抗生素治疗感染的住院病例进行了回顾性分析.
- 基于病理生理机制和临床亚型的抗生素的分类.
- 主要结果:AAE发生率;二次分析包括GFR和EEG发现.
主要成果:
- 与2型相比,1型抗生素与明显更高的AEA发病率有关 (aOR,2.62).
- 组合疗法 (1+2型) 显示AAE发病率高于2型单一疗法 (aOR,3.44).
- 较低的GFR (<60毫升/分钟/1.73米2) 和特定的EEG模式 (尖端波) 与AAE风险增加有关,特别是在组合治疗中.
结论:
- 与单一治疗相比,联合使用抗生素与AAE的发病率更高有关.
- 降低功能 (GFR <60) 显著增加了AAE发病率.
- 在接受联合抗生素的患者中,脑电图上的性泄露更有可能发生,这表明与AAE有联系.
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