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Updated: Jun 28, 2025

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
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Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

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贝塔抑制剂或安慰剂用于食道变节的初级预防 (BOPPP):随机对照试验的研究协议

Vishal C Patel1,2,3, Mark J McPhail4,5, Ruhama Uddin4

  • 1Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK. vishal.patel@nhs.net.

Trials
|April 16, 2024
PubMed
概括

这项研究调查了非选择性β-阻断剂卡维迪醇是否可以预防小静脉动脉的肝硬化患者的肝脏衰退. 结果将决定早期干预的临床和成本效益.

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Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
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β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
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Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
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Third-generation β-blockers, such as labetalol and carvedilol, represent a significant advancement in managing cardiovascular conditions. Unlike conventional β-blockers, which can induce peripheral vasoconstriction, third-generation drugs block α1 adrenoceptors. This promotes vasodilation through several mechanisms, such as increased nitric oxide production, inhibition of calcium ion entry, opening of potassium ion channels, and antioxidant action. Labetalol, for instance, is...
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