方案治疗与常规治疗对于难以治疗抑郁症的门诊患者:平行组随机临床试验 (DEPRE-ST) 的研究方案
Ida-Marie T P Arendt1,2, Matthias Gondan3, Sophie Juul4,5
1Department of Psychology, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark. imarendt@health.sdu.dk.
Trials
|April 16, 2024
概括
方案治疗可以改善难以治疗的抑郁症的结果. 这项试验将30次方案治疗与通常治疗进行比较,评估24个月的抑郁症状和生活质量.
科学领域:
- 临床心理学 临床心理学
- 精神病学是一个精神病学.
- 卫生经济学 卫生经济学
背景情况:
- 大约三分之一的抑郁病例难以治疗,通常与童年创伤和人格障碍有关.
- 心理治疗对于难以治疗的抑郁症的有效性仍然不确定,这突出了当前治疗理解的差距.
- 本研究涉及丹麦公共精神卫生部门中研究不足的难以治疗的抑郁症领域.
研究的目的:
- 为了评估与通常治疗相比,30次单独方案治疗的有益和有害影响.
- 评估方案治疗难以治疗抑郁症患者的成本效益.
主要方法:
- 一个随机的,多中心的,平行组优势试验,涉及129名难以治疗抑郁症的门诊患者.
- 参与者被随机分配 (1:1) 接受个人方案治疗或通常的治疗 (主要是基于小组的CBT或精神动态疗法).
- 主要结局:12个月后抑郁症状的变化 (汉密尔顿抑郁症评分表). 二次结果包括生活质量,功能障碍,幸福感和负面影响,在6,12和24个月评估.
主要成果:
- 该试验旨在提供关于方案治疗疗法的疗效和安全性的证据.
- 它将评估抑郁症状,生活质量,功能障碍和心理健康的变化.
- 探索性结果包括患者定义的目标,恢复,焦虑,愤怒和认知模式.
结论:
- 这项试验将提供关于方案治疗难以治疗抑郁症的有效性和成本效益的关键数据.
- 这些发现有可能显著提高大量和服务不足的患者群体的治疗策略.
- 这项研究旨在为临床实践提供信息,并改善与持久性抑郁症状作斗争的个体的结果.
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