对手术后神经认知功能的普罗波和德斯弗对比在患有神经瘤下关节出血的患者中:一项前性随机试验
Shalvi Mahajan1, Tanavi Sharma2, Nidhi Bidyut Panda1
1Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
与德斯弗兰相比,在手术后一个月,普罗波 (propofol) 麻醉显示认知得分有所改善,特别是在记忆和定向方面. 虽然在统计学上显著,但在接受动脉瘤手术的患者中,这些发现的临床意义需要进一步调查.
科学领域:
- 麻醉学 麻醉学
- 神经外科 神经外科
- 神经科学是一个神经科学.
背景情况:
- 脑瘤下关节出血的幸存者经常经历认知功能障碍,影响生活质量.
- 麻醉剂在动脉瘤手术中至关重要,但它们的神经认知效应尚未得到充分证实.
- 这项研究调查了propofol与desflurane对术后神经认知的影响.
研究的目的:
- 为了评估普罗波福和德斯弗对动脉瘤手术后神经认知功能的影响.
- 为了比较接受普罗波和德斯弗兰的患者之间的血清S-100B水平.
主要方法:
- 100名患者被随机分配给接受普罗波或德斯弗.
- 用蒙特利尔认知评估尺度评估认知功能在手术前,在出院时和手术后一个月.
- 在外科手术期间测量了血清S-100B水平.
主要成果:
- 认知分数在两组都在放药时显著下降,但在两组之间是可比的.
- 手术后一个月,在普罗波 (P=0.04) 组的认知分数显著更高.
- 亚组分析显示,使用普罗波的记忆和定向得分更好 (P<0.05);血清S-100B水平相似.
结论:
- 与desflurane相比,propofol在手术后一个月显著改善了认知得分.
- 虽然在统计学上显著,但这些认知改善的临床意义需要进一步评估.
- 与desflurane相比,propofol可以更好地保护导向和记忆领域.
更多相关视频
14:52Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
Published on: January 13, 2018
08:16Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
相关概念视频
Parenteral Anesthetics: Overview
Stages of General Anesthesia
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Inhalational Anesthetics: Overview
Depolarizing Blockers: Pharmocokinetics
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
