omega-3补充剂或饮食对女性生育能力的影响:元分析
Shivtia Trop-Steinberg1, Michael Gal2,3, Yehudith Azar4
1Jerusalem College of Technology, Faculty of Life and Health Science, P.O.B. 16031, Jerusalem, Israel.
Heliyon
|April 17, 2024
概括
摄入欧米茄-3脂肪酸显著提高了女性的怀孕和受精率. 这一发现支持欧米茄-3为女性生育有益,尽管需要更多的研究.
科学领域:
- 生殖医学 生殖医学
- 营养科学 营养科学
- 证据综合 证据综合
背景情况:
- 现有的关于omega-3脂肪酸和女性生育能力的研究提出了相互矛盾的观点.
- 对于试图自然受孕的女性,数据有限.
- 欧米茄-3脂肪酸是必需的营养素,在生殖健康方面具有潜在的作用.
研究的目的:
- 系统地审查和元分析增加欧米茄-3消费对女性受精和怀孕率的影响.
- 评估omega-3脂肪酸对接受生育治疗 (IVF/ICSI) 和自然怀孕的妇女的疗效.
主要方法:
- 在多个数据库 (PubMed,Cochrane Library等) 中进行了全面的文献搜索. 在2021年4月之前.
- 包括的研究重点是女性生育能力 (自然或辅助) 和omega-3摄入量,不包括绝经后妇女和不均匹配组.
- 进行了元分析,使用几率比率来综合临床怀孕和受精率的数据,并使用Cochrane手册进行了偏差评估.
主要成果:
- 该审查包括六项试验 (1789名妇女) 进行生育治疗,四项试验 (2607名妇女) 进行自然受孕,以及三项试验 (1725个卵细胞) 进行受精率.
- 摄入欧米茄-3有显著的积极影响:生育治疗的几率比 (OR) 为1.74,自然受孕的几率为1.36和受精率为2.14 (p ≤0.01).
- 在包括的研究中发现了很高的异质性 (I2>68%),表明结果的变化.
结论:
- 摄入欧米茄-3与女性受精率和怀孕率的显著改善有关.
- 观察到的好处表明,欧米茄-3脂肪酸可能在提高女性生殖结果方面发挥关键作用.
- 高异质性需要谨慎解释,并强调需要进一步的前性随机对照试验来证实这些发现.
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