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发现B型肝炎病毒表面抗原抑制剂GS-8873

Darryl Kato1, Regina Wai-Yan Choy1, Eda Canales1

  • 1Gilead Sciences, Foster City, California 94404, United States.

ACS medicinal chemistry letters
|April 17, 2024
PubMed
概括

研究人员开发了一种新的药物GS-8873,通过抑制HBsAg来向慢性乙型肝炎 (CHB). 这种可口服的化合物旨在恢复免疫功能,为CHB感染提供潜在的功能治愈.

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Hepatitis01:25

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...