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Updated: May 14, 2026

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使用DNA编码的聚焦库对SARS-CoV-2 PLpro进行化学空间分析

Xudong Wang1,2, Ying Zhu3, Qingyi Zhao3

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China.

ACS medicinal chemistry letters
|April 17, 2024
PubMed
概括

用DNA编码的图书馆 (DELs) 快速识别了SARS-CoV-2类似帕帕因蛋白酶的新型碎片. 有前途的衍生品显示出强大的抑制作用,突出显示了抗病毒药物发现的DEL.

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...