同生菌调节狼性炎患者的肠道微生物群:使用元基因组和代谢组测序的分析
Qiuyu Zhu1, Jiuming Cui1, Sen Liu1
1Department of Nephrology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Frontiers in microbiology
|April 17, 2024
概括
在狼性炎患者中,共生菌改变了肠道细菌和代谢物,可能提供新的治疗点. 这些补充剂在治疗狼性炎 (LN) 方面似乎是安全和有前途的.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 狼性炎 (LN) 是一种影响脏的自身免疫性疾病.
- 肠道微生物群失生症与LN病原发生有关.
- 协生菌,结合益生菌和益生菌,可以调节肠道微生物群.
研究的目的:
- 研究共生菌对肠道微生物群和新发性狼性炎 (LN) 患者的代谢物的影响.
- 根据微生物和代谢变化来确定LN的潜在诊断和治疗点.
主要方法:
- 12名患有新发性LN的参与者被分为狼和共生组.
- 在治疗前和治疗后收集了便样本和临床数据.
- 进行了元基因组,代谢和统计分析.
主要成果:
- 同生菌治疗减少了致病细菌 (Prevotella, Bacteroides, Enterobacteriaceae) 和增加了有益的细菌 (Actinobacteria, Firmicutes).
- 虽然Firmicutes/Bacteroidetes的比率增加了,但从统计学上来说并不显著.
- 没有观察到α多样性的显著变化,但β多样性分析显示了社区结构的差异.
- 阴性细胞和未分类的Enterobacteriaceae被确定为关键预测因素.
- 协生菌影响了包括氨基酸和纯素代谢在内的代谢途径.
- 观察到临床特征和肠道菌群之间的复杂相互作用.
结论:
- 在LN患者中,共生菌调节肠道微生物的代谢功能.
- 这些微生物和代谢变化表明,共生菌在与LN相关的各种生物功能中发挥了作用.
- 协生菌补充剂证明了安全性和潜力,作为狼性炎的治疗候选药物.
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