导致HIV感染和长期ART视网膜变化的炎症机制
Lungile M Buthelezi1, Alvin J Munsamy1, Khathutshelo P Mashige1
1Department of Optometry, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Southern African journal of HIV medicine
|April 17, 2024
概括
长期接受抗逆转录病毒治疗 (ART) 的艾滋病毒感染者面临眼睛风险增加. 慢性炎症和ART毒性会损害视网膜,影响视力,但需要对视觉功能的影响进行更多研究.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 长期接受抗逆转录病毒治疗 (ART) 的艾滋病毒感染者 (PLWH) 容易患上与年龄有关的眼睛并发症.
- 慢性炎症和ART诱导的毒性可以导致PLWH的视网膜变化.
- 了解这些机制对于管理这一群体的眼睛健康至关重要.
研究的目的:
- 审查炎症途径如何导致长期接受ART的PLWH视网膜变化.
- 探索HIV感染和ART在造成视网膜损伤方面的相互作用.
- 为了确定内视网膜变化的病变发生的关键因素.
主要方法:
- 在Scopus,Hinari,谷歌学者和PubMed (1996-2022) 的系统文献搜索.
- 包括临床试验,元分析,随机对照试验和系统审查.
- 专注于研究炎症途径和视网膜变化的研究.
主要成果:
- 失调的偏炎症会损害血视网膜屏障,损害视网膜免疫特权,改变视网膜和血管.
- 由ART诱导的线粒体毒性会引起氧化应激,损害视网膜质细胞和视网膜色素上皮 (RPE).
- 艾滋病毒感染也会影响视网膜微质,导致RPE损伤并影响血管.
结论:
- 评估血视网膜屏障的完整性是理解视网膜内部变化的关键.
- 光学连贯性断层扫描是评估结构变化的宝贵工具.
- 需要进一步的研究来将结构变化与视觉功能缺陷联系起来,例如对比度和色彩视觉.
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