在入院时临床稳定COVID-19住院患者的预防性抗凝血和血栓形成:从基于实践的观察性研究
Yugo Yamashita1, Sen Yachi2, Makoto Takeyama2
1Department of Cardiovascular Medicine, Kyoto University Hospital, Kyoto, Kyoto, Japan.
Annals of vascular diseases
|April 17, 2024
概括
在稳定住院的COVID-19患者中,预防性抗凝剂无法预防血栓形成. 在住院期间病情恶化的患者更有可能接受抗凝药,并具有更高的血栓形成风险.
科学领域:
- 内部医学 内部医学
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
背景情况:
- 在稳定的住院COVID-19患者中预防性抗凝剂的作用仍在争论中.
- 观察性研究对于理解现实世界治疗效应至关重要.
研究的目的:
- 评估2019年轻型冠状病毒疾病 (COVID-19) 的住院患者的预防性抗凝血和血栓形成风险之间的关联.
主要方法:
- 一项多中心观察研究 (CLOT-COVID) 分析了1738名住院的COVID-19患者,最初稳定且不需要氧气.
- 患者被分为两组:接受预防性抗凝药的患者 (n=326) 和未接受抗凝药的患者 (n=1412).
主要成果:
- 接受预防性抗凝药的患者在住院期间表现出更严重的COVID-19过程,与没有接受预防性抗凝药的患者相比.
- 血栓形成发生在0.5%的患者中,在那些患有更严重的COVID-19的人群中,血栓形成的数量更高.
- 没有恶化的患者很少患有血栓塞,无论抗凝药状态如何.
结论:
- 在稳定的住院COVID-19患者中,预防性抗凝剂似乎没有降低血栓形成风险.
- 住院后COVID-19严重程度的恶化与抗凝血剂使用增加和血栓形成的风险增加有关.
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