低水平病毒病与艾滋病毒感染者的严重非艾滋病事件有关
Anuradha Ganesan1,2,3, Hsing-Chuan Hsieh1,3, Xiuping Chu1,3
1Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Open forum infectious diseases
|April 17, 2024
概括
艾滋病毒感染者的低水平病毒性病 (LLV) 与严重的非艾滋病事件 (SNAE) 有关. 这项研究强调了LLV与SNAE风险增加之间的关联,强调了需要进一步研究的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 艾滋病毒感染者的低水平病毒血症 (LLV) 的临床意义仍然不完全理解.
- 之前的研究尚未确定LLV与不良健康结果之间的联系.
研究的目的:
- 调查低水平病毒性病 (LLV) 与艾滋病毒感染者的严重非艾滋病事件 (SNAE) 发生率之间的关联.
- 量化SNAE风险与抗逆转录病毒治疗期间不同水平的病毒血症相关.
主要方法:
- 分析了美国军事HIV自然史研究的数据,包括1996年后开始抗逆转录病毒治疗的参与者.
- 病毒载荷 (VLs) 的分类为病毒抑制 (VS; <50副本/毫升),低水平病毒性病 (LLV; 51-199副本/毫升),较高水平的低水平病毒性病 (HLLV; 200-999副本/毫升) 和病毒性失败 (VF; 2+次≥200副本/毫升或一次≥1000副本/毫升).
- 使用Cox比例危险模型来评估LLV类别和SNAE之间的关联,报告了调整的危险比率 (aHR) 和95%置信区间 (CI).
主要成果:
- 在2528名参与者中,他们被跟踪了平均11年,其中439人 (17.4%) 经历了SNAEs.
- 在8.5%和4.6%的参与者中,LLV和HLLV是记录的病毒性层次最高.
- 与病毒抑制 (VS) 相比,SNAE与LLV (aHR=1.3,95%CI [1.2-1.4]),HLLV (aHR=1.6,95%CI [1.5-1.7]) 和病毒失败 (aHR=1.7,95%CI [1.7-1.8]) 有意义地相关.
结论:
- 低水平病毒性病 (LLV) 与艾滋病毒感染者的严重非艾滋病事件 (SNAE) 风险增加有显著关联.
- 这些发现强调了保持病毒抑制的重要性,并表明LLV值得进一步调查,因为它是潜在的发病风险因素.
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