聚合物在化衍生的血小板度:一个5年的单中心经验
Matea Vinković1,2, Ana Hećimović3, Irena Jukić2,3
1Research and Development Department, Croatian Institute of Transfusion Medicine, Zagreb, Croatia.
Vox sanguinis
|April 17, 2024
概括
甲酶衍生血小板缩物 (APC) 中的持久聚合物导致更高的丢弃率. 虽然非热技术影响初始可见聚合物 (IVA),但捐赠因素可能会导致APC中的持久聚合物 (PA).
科学领域:
- 输血医学 输血医学
- 血液学 血液学 血液学
- 血液成分加工 血液成分加工
背景情况:
- 血小板缩物 (APC) 中的可见聚合物 (IVA) 通常在24小时内消失.
- 持久聚合物 (PA) 保持在整个保质期内,影响血小板度的质量.
- 影响APC聚合物形成的因素需要进一步阐明.
研究的目的:
- 为了确定导致APC出现可见聚合物 (IVA) 和持久聚合物 (PA) 的因素.
- 为了分析由于PA而丢弃的APC,比较两个非技术.
- 为了将带有PA的 APC 与对照组进行比较.
主要方法:
- 从2018-2022年进行的横截面研究.
- 收集了对表现为IVA的 APC 的数据.
- 分析了由于PA而丢弃的APCs,通过异位技术分层 (Amicus和Haemonetics),并与对照进行了比较.
主要成果:
- 与对照组相比,装有IVA的APC的丢弃率明显更高.
- 205辆 APC (1.27%的总量) 因PA而被丢弃.
- 有PA的阿米库斯APC显示血小板数量和血小板平均体积较低,使用的抗凝剂较少. 血红学与PA的APC具有更高的血小板计数.
- 没有发现与捐赠者相关的因素可以预测PA.
结论:
- 由于总体问题和其他质量参数损害,具有IVA的APC经常被丢弃.
- 已知IVA风险因素的阿费雷西斯技术并未被证实是PA的主要风险因素.
- 与捐赠者相关的因素似乎在APC中持续聚合物的发展中发挥了作用.
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