长期服用皇家果可以调节与年龄相关的疾病,并改善自然衰老小鼠的肠道功能
Lili Chen1,2, Li Zhao2, Gaowei Zhang1
1Key Laboratory of Geriatric Nutrition and Health Ministry of Education, College of Food and Health, Beijing Technology and Business University, Beijing, 100048, China. lluo2@126.com.
Food & function
|April 17, 2024
概括
在老年小鼠中补充皇家果 (RJ) 改善了肠道健康,减少了炎症,并调节了肠道微生物群. 这种饮食干预显示出对抗与年龄相关的脆弱性和改善代谢健康的潜力.
科学领域:
- 老年学和衰老研究研究.
- 微生物学和肠道健康
- 营养科学和自然产品
背景情况:
- 自然衰老的老鼠模型密切模仿人类衰老生理学.
- 皇家果 (RJ) 在实验模型中证明了各种健康益处.
- RJ对自然衰老的小鼠的影响,特别是肠道健康,仍未得到充分研究.
研究的目的:
- 为了研究长期皇家果 (RJ) 补充剂对老年小鼠的影响.
- 评估RJ对肠道屏障功能,肠道微生物群和短链脂肪酸 (SCFA) 的影响.
- 探索RJ抗衰老作用的潜在机制.
主要方法:
- 中年雄性C57BL/6J小鼠接受了RJ治疗,持续了9个月.
- 评估了血清脂质样本,肝脏保护标记物 (抗氧化酶,炎症细胞因子) 和细胞循环抑制剂 (p16,p21,p53).
- 评估肠道屏障完整性 (紧结蛋白),结肠炎症,肠道微生物群组成和SCFA水平.
主要成果:
- RJ调节血清脂质,降低总胆固醇,甘油三和LDL-C.
- 通过增强抗氧化酶和降低TNF-α,IL-6和IL-1β,RJ保护了肝脏.
- RJ改善了肠道功能障碍,保留了紧结蛋白,并减少了结肠炎症.
- 瑞杰改变了肠道微生物群,增加了Firmicutes/Bacteroides比率和有益的细菌,如Lachnospiraceae NK4A136和Akkermansia.
- RJ干预积极调节了氨基酸,甘氨酸和辅因子/维生素代谢.
结论:
- 皇家果 (RJ) 对老年小鼠有显著的益处,改善了肠道屏障功能并减少了炎症.
- 补充RJ可以积极调节肠道微生物群的组成,并增强短链脂肪酸的产生.
- 干预RJ提供了一种有希望的饮食策略,可以缓解与年龄相关的脆弱性,并改善代谢和肝脏健康.
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