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成年患有先天性心脏病的患者中的心律失常负担:基于人口的研究
Nili Schamroth Pravda1, Ofra Kalter-Leibovici2,3, Amiram Nir4
1Department of Cardiology Adult Congenital Heart Disease Unit, Rabin Medical Center Petach Tikva Israel.
心律失常在患有先天性心脏病的成年人中很常见,增加了住院和死亡风险. 这些心律失常的早期发现和治疗对于改善患者的治疗结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 成年人的先天性心脏病
- 电子生理学 电子生理学
背景情况:
- 患有先天性心脏病 (ACHD) 的成年人患心律失常的风险很高.
- 这些心律失常与不良事件和死亡率增加有关.
- 了解ACHD中心律失常的患病率对于患者护理至关重要.
研究的目的:
- 为了确定心律失常的流行率在一个大型的国家队列的ACHD患者.
- 为了确定与心律失常发展相关的危险因素.
- 评估心律失常对医疗保健利用率和生存率的影响.
主要方法:
- 这是一项对11653名ACHD患者 (2007-2011) 的回顾性队列研究.
- 基线心律失常率和新发性心律失常的分析.
- 用于评估住院和死亡风险的统计模型 (负二项式和Cox比例风险).
主要成果:
- 在ACHD患者中,8.7%的患者在基线时出现了动脉节律失常;在随访期间,9.2%的患者出现了新的动脉节律失常.
- 心律失常与显著更高的住院率 (1.27-1.33倍增加) 相关.
- 大心室和心室动脉节律失常显著增加死亡风险 (HR分别为1.65和2.06).
结论:
- 节律失常是ACHD人群中普遍存在的并发症,并且具有重要意义.
- 这些心律失常会对医疗保健的使用和患者的生存率产生重大影响.
- 在ACHD中,有效的心律失常管理策略至关重要.
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