大脑结构和功能连接性将童年累积创伤与COVID-19连接起来代理创伤
Xiqin Liu1,2,3, Yajun Zhao4, Jingguang Li5
1Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, China.
概括
在COVID-19期间的代理创伤 (VT) 与大脑结构和连接性差异有关. 童年创伤史通过这些神经标记影响了VT,为心理健康治疗提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 心理健康 心理健康
背景情况:
- 代理创伤 (VT) 是对COVID-19大流行病的心理反应.
- 个人创伤史影响VT,但其神经机制尚不清楚.
- 了解VT的神经基础对于心理健康至关重要.
研究的目的:
- 确定神经生物学标志物用于静脉瘤的个体差异.
- 研究童年累积创伤 (CCT) 和静脉创伤之间的神经联系.
- 探索与COVID-19相关的VT相关的大脑结构和功能.
主要方法:
- 在年轻成年人身上使用结构性和静止状态功能性MRI (rs-fMRI) (N=115).
- 与灰色物质体积 (GMV) 和静止状态功能连接 (RSFC) 相关联的VT水平.
- 研究了大脑标志物如何将CCT与静脉治疗联系起来.
主要成果:
- 静脉瘤与右背侧前额 (DLPFC) 中的GMV正相关.
- 在右DLPFC和右先骨之间RSFC与VT负相关.
- 右边的DLPFC体积和DLPFC-precuneus RSFC调解了CCT-VT关系.
结论:
- 确定了对静脉瘤的结构性 (DLPFC体积) 和功能性 (DLPFC-precuneus RSFC) 大脑标记物.
- 这些标记物代表了一个潜在的神经机制,将CCT与COVID相关的静脉治疗联系起来.
- 这些发现对预防和治疗与创伤相关的精神障碍有影响.
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