在儿童轻度创伤性脑损伤后嗅觉功能 - 一项纵向病例对照研究
Janine Gellrich1,2, Claudia Zickmüller1, Theresa Thieme1
1Abteilung Neuropädiatrie, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Cerebral cortex (New York, N.Y. : 1991)
|April 17, 2024
概括
患有轻度创伤性脑损伤的儿童通常会经历嗅觉障碍,特别是在检测气味方面. 这种嗅觉功能障碍影响33%的儿科患者,并可能持续一年,影响日常生活.
科学领域:
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 儿科 儿科 儿科
背景情况:
- 创伤后嗅觉功能障碍是创伤性脑损伤 (TBI) 的已知并发症.
- 儿童患病率估计差异很大 (3-58%),需要进一步研究影响因素和评估方法.
- 嗅觉功能障碍会显著影响孩子的生活质量,影响饮食,安全和社会互动.
研究的目的:
- 为了前性地研究轻度创伤性脑损伤 (mTBI) 与儿童嗅觉功能障碍之间的关联.
- 为了确定小儿mTBI后嗅觉功能障碍的患病率和持续性.
- 探索mTBI症状和嗅觉缺陷之间的潜在相关性.
主要方法:
- 一项前性纵向研究,涉及75名被诊断患有mTBI的儿科患者和年龄相匹配的健康对照组.
- 使用Sniffin' Sticks电池评估嗅觉功能,评估嗅觉值和气味识别.
- 在一年内进行了后续评估,以监测嗅觉功能的恢复.
主要成果:
- 与健康对照组相比,患有mTBI的儿童显示嗅觉功能明显受损,特别是在嗅觉值.
- 儿科mTBI组的嗅觉功能障碍的患病率为33%,持续至少一年.
- 在常见的mTBI症状 (例如,记忆丧失,意识丧失) 与嗅觉功能障碍的存在或严重程度之间没有发现显著的关联.
结论:
- 嗅觉功能障碍是儿童轻度创伤性脑损伤后的常见和持续的并发症.
- 在对患有mTBI的儿童进行临床治疗时,应考虑常规的嗅觉功能评估.
- 需要进一步的长期后续研究,以充分阐明儿科mTBI后嗅觉功能的恢复轨迹.
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