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免疫调节模式对环境污染物染色体暴露相关的遗传损伤的反应:应用机器学习方法的跨部分研究

Zekang Su¹, Yali Zhang¹, Shiyi Hong¹

¹Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.

Environmental science & technology

|April 17, 2024

概括

六价暴露增加了与免疫系统调节相关的遗传损伤. 机器学习揭示了像PD-1和PD-L1这样的免疫标记在暴露的工人中调解这种诱导的DNA损伤.

科学领域:

环境健康环境健康
免疫学免疫学免疫学
毒理学毒理学毒理学

背景情况:

六价 (Cr) 暴露是一种已知的致癌物,会损害DNA和染色体.
在Cr诱导的癌症风险背后的免疫机制研究不足.
免疫调节分子对于癌症的发展和进展至关重要.

研究的目的:

调查血水平与遗传损伤生物标志物之间的关联.
探索免疫调节机制的作用,包括共刺激分子,在染色体暴露的工人中.
通过机器学习阐明暴露,遗传损伤和免疫反应之间的关系.

主要方法:

在120名暴露于染色体的工人中测量了血水平,尿液中的8-基-2'-脱氧氨酸 (8-OHdG) 和血液微核频率 (MNF).
探索性因子分析和机器学习被用来分析免疫调节模式.
评估了PD-1,PD-L1,LAG-3和NLRP3等免疫标记物对Cr基因损伤关联的影响.

主要成果:

较高的血Cr水平与增加的遗传损伤 (升高的8-OHdG和MNF) 呈现线性相关性.
积极和消极的免疫调节模式都与血液Cr水平有关.
免疫检查点分子 (PD-1,PD-L1,LAG-3) 和NLRP3炎症体参与调解Cr暴露与遗传损伤/炎症之间的关系.

结论:

血水平与暴露工人的遗传损伤增加直接相关.
免疫调节通路,包括免疫检查点蛋白和炎症体,在调解染色体诱导的遗传损伤方面发挥着重要作用.
进一步的研究是有必要的,以充分理解这些复杂的免疫媒介机制在Cr毒性.

关键词:

在NLRP3中,NLRP3是NLRP3中的一个.血液中的.它们是共刺激分子.遗传损害遗传损害是一种遗传损害.调解分析调解分析

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