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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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一种高度生物相容的CE-crosslinked原体植入物,具有特殊的抗化和原体再生能力,用于老化皮肤的复苏和青春.

Qi Wang1,2, Huiyu Yan1,2, Linyan Yao1,2

  • 1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China. xiaojx@lzu.edu.cn.

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一种使用新型交联剂 (CE) 的新型生物相容原体植入物有效地使老化皮肤复苏. 这种CE-crosslinked原蛋白促进再生,减少纹而无需化,为皮肤治疗提供更安全的替代方案.

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科学领域:

  • 生物材料科学 生物材料科学
  • 皮肤病学 皮肤病学
  • 再生医学是一种再生医学.

背景情况:

  • 皮肤衰老涉及纹和松由于原降解.
  • 传统的原交联剂存在细胞毒性和化等风险.
  • 需要更安全,更有效的原基材料用于皮肤再生.

研究的目的:

  • 开发一种高度生物相容的原体植入物,用于老化皮肤的再生.
  • 评估一种新的原交联剂 (CE),以提高其稳定性,生物相容性和抗化特性.
  • 评估CE交联原蛋白在促进皮肤原蛋白再生中的有效性.

主要方法:

  • 从酸盐四级盐和1,4-butanediol diglycidyl ether合成了一种新的原交联剂 (CE).
  • 与CE交叉连接的原蛋白,并将其特性 (稳定性,可注射性,粘度) 与甲基 (GA) 交叉连接的原蛋白进行比较.
  • 使用HFF-1细胞增殖和粘附试验评估生物相容性.
  • 进行了活体实验以评估老年皮肤中的原体再生和化.

主要成果:

  • 与GA交叉连接的原蛋白相比,CE交叉连接的原蛋白植入物表现出优越的稳定性,耐用性,注射性和粘度.
  • 经CE交联的原体表现出增强的生物相容性,促进HFF-1细胞的增殖和粘附.
  • 活体研究证实了显著的原再生,而不会诱导化.

结论:

  • 新型CE-crosslinked原体植入物是一种安全有效的材料,用于老化皮肤的再生.
  • 这种创新的植入物促进原再生,减少纹,在美学皮肤病学中提供了有前途的进步.
  • 与传统方法相比,CE-crosslinking是一个显著的改进,最大限度地降低了与细胞毒性和化相关的风险.