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Updated: Jun 28, 2025

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肠道病毒71激活了依赖于状细胞的等离子细胞体PSGL-1结合,独立于生产性感染

Xuyuan Zhang¹, Zhao Yin², Jialong Zhang¹

¹National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Journal of immunology (Baltimore, Md. : 1950)

|April 17, 2024

概括

肠道病毒71 (EV71) 使用细胞受体SCARB2和PSGL-1来感染免疫细胞. 结合PSGL-1是EV71在血细胞树突细胞 (pDC) 和IFN-α产生中的重复的关键,这可能会影响疾病的严重程度.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

肠道病毒71 (EV71) 导致手,脚和口腔疾病,并导致严重的神经并发症.
由于其复杂的致病性,EV71感染缺乏有效的治疗方法.
人类等离子细胞状树突细胞 (pDCs) 是I型干扰素的关键生产者.

研究的目的:

调查EV71与人类pDCs之间的相互作用.
为了确定参与EV71进入和复制pDCs中的细胞受体.
了解pDCs和IFN-α在EV71病变发生中的作用.

主要方法:

在pDC中分析SCARB2和PSGL-1的表达.
在pDC中进行EV71感染测定.
使用抗体和SCARB2和PSGL-1的可溶性形式的抑制研究.
干扰素α (IFN-α) 生产试验.

主要成果:

pDCs表达SCARB2和PSGL-1,它们作为EV71.1.的受体.
结合PSGL-1的EV71菌株在pDC中复制并诱导IFN-α分泌,与严重病例相关.
pDC激活和IFN-α分泌可以独立于生产性EV71感染.
对PSGL-1的抗体显著抑制了pDCs的EV71激活.

结论:

PSGL-1在pDCs中的EV71复制和随后的IFN-α生产中发挥着关键作用.
EV71与pDCs的相互作用,特别是通过PSGL-1,会影响疾病的结果.
pDC激活代表了一个潜在的治疗目标,以减轻EV71疾病的严重程度.

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