亚斯科布酸作为对白虫 (Candida albicans) 的炎症反应调节剂
Noala Vicensoto Moreira Milhan1, Aline da Graça Sampaio1, Cristiane Yumi Koga-Ito1
1Department of Environmental Engineering & Sciences Applied in Oral Health Graduate Program, São Paulo State University (Unesp), Institute of Science & Technology, São José dos Campos, São Paulo, 12245-000, Brazil.
Future microbiology
|April 17, 2024
概括
维生素C (Vit C) 对口服角质细胞没有细胞毒性,但增强了其代谢活性. 这项研究表明维生素C.
科学领域:
- 口腔生物学 口腔生物学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 口腔角质细胞在口腔粘膜对病原体的防御中起着至关重要的作用.
- 炎症是口腔疾病的关键因素,包括由Candida albicans引起的疾病.
- 维生素C (Vit C) 以其抗氧化和免疫调节特性而闻名.
研究的目的:
- 研究维生素C对口腔角质细胞行为的影响,包括代谢活性和细胞迁移.
- 为了评估维生素C在口腔皮细胞中具有的抗炎潜力,这些皮细胞受到Candida albicans的挑战.
主要方法:
- 口服角质细胞被用不同度的维生素C (0.1-2.5毫米) 治疗.
- 使用MTS试验评估新陈代谢活动,使用伊比迪培养插件评估细胞迁移.
- 暴露于维生素C后,细胞被Candida albicans挑战,并通过qPCR分析炎症标记基因表达 (IL-8,IL-1β).
主要成果:
- 维生素C治疗对口服角质细胞没有细胞毒性.
- 维生素C的较高度在24小时后增加了代谢活性.
- 维生素C在48小时和72小时延迟了细胞迁移.
- 维生素C显著降低了炎症基因IL-8和IL-1β的表达.
结论:
- 维生素C对口腔角质细胞具有非细胞毒性作用.
- 维生素C通过减少关键的炎症标志物,表现出抗炎性质.
- 维生素C可以作为一种有益的辅助剂,用于治疗口腔疾病的抗真菌药物.
相关概念视频
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
161
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
161
01:29Drugs for Treatment of Ulcerative Colitis in IBD
138
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
138