结肠镜镇静类型与多胞体检测之间的关联:基于注册表的队列研究
Aurora N Quaye1, William M Hisey2, Todd A Mackenzie3
1Department of Anesthesiology and Perioperative Medicine, Maine Medical Center, Portland, Maine; Division of Anesthesiology, Spectrum Healthcare Partners, South Portland, Maine; Assistant Professor of Anesthesiology, Tufts University School of Medicine, Boston, Massachusetts.
在结肠镜检查过程中使用普罗波镇静剂可以改善状息肉的检测,这是一种难以发现的结肠直肠癌的前体. 这项研究发现,与中度镇静相比,使用普罗波与较高的状息肉检测率有关.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 麻醉学 麻醉学
背景情况:
- 大肠直肠癌 (CRC) 是癌症死亡的一个重要原因.
- 腺瘤和有的息肉是CRC的前体,有的息肉在结肠镜检测过程中构成检测挑战.
- 普罗波镇静对多检测的影响需要进一步调查.
研究的目的:
- 在结肠镜检查期间检测腺瘤和状息肉时,研究基于普罗波的镇静与轻度至中度镇静之间的关联.
- 在大量患者队列中,比较不同镇静方法之间的多检测率.
主要方法:
- 使用来自新罕布什尔州结肠镜注册表 (2015-2020) 的数据进行了回顾性队列研究.
- 包括50岁以上接受查/监视结肠镜检查的患者;不包括诊断检查,没有镇静,缺少数据或准备不足.
- 用多变量逻辑回归和倾向得分调整来分析和中度镇静剂之间的多胞体检测差异.
主要成果:
- 分析包括54,063例结肠镜 (全样本) 和18,998例 (受限样本).
- 在这两种样本中, пропофол镇静与状息肉的明显更高的患病率有关.
- 多变量分析表明,在全样本中,醇与瘤,腺瘤和状息肉的检测增加有关;在受限样本中,对状息肉的影响减弱,但显著.
结论:
- 普罗波福尔镇静剂可能会在结肠镜检查期间增强状息肉的检测.
- 在使用普罗波和腺瘤检测之间没有发现显著的关联.
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