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Updated: Jun 28, 2025

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

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主要负面的OTULIN相关的自身炎症综合征

Sophia Davidson1,2, Yuri Shibata2,3, Sophie Collard1,2

  • 1Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.

The Journal of experimental medicine
|April 17, 2024
PubMed
概括

在OTULIN的新的主导负基因突变导致OTULIN相关的自身炎症综合征 (ORAS). 这种突变扰乱了duebiquitinase的活性,导致炎症信号失调和细胞死亡增加.

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