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Updated: Jun 28, 2025

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多发性骨髓瘤中的血栓预防:一个基于病例的综述,附有实践指南

Charalampos Charalampous¹, Darshi Shah², Shaji Kumar¹

¹Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Annals of hematology

|April 17, 2024

概括

静脉血栓栓塞 (VTE) 在多发性骨髓瘤中很常见. 本综述探讨了VTE风险评估模型和个性化预防,强调为最佳患者护理量身定制的策略.

科学领域:

血液学血液学血液学
在瘤学瘤学.
临床医学临床医学

背景情况:

静脉血栓塞栓症 (VTE) 是多发性骨髓瘤 (MM) 患者的重大并发症.
在新诊断的MM中,VTE发病率高达10%,并且在复发/耐药情况下有所不同.
有效的VTE风险评估和个性化血栓预防对于MM的支持性护理至关重要.

研究的目的:

审查VTE风险预测模型在当前多发性骨髓瘤治疗中的实际应用.
强调需要采用量身定制的方法,整合患者特异性,疾病特异性和治疗特异性的因素.
总结VTE预防数据,并强调有利于MM患者直接口服抗凝剂的情况.

主要方法:

在多发性髓瘤中对VTE风险评估模型 (SAVED,IMPEDE-VTE,PRISM) 的当前文献的综述.
分析患者特异性,疾病特异性和治疗特异性风险因素.
关于VTE血栓预防策略的现有数据摘要,包括直接口服抗凝剂.

主要成果:

对于新诊断的多发性骨髓瘤,现有三种经过验证的VTE风险评估模型.
结合模型输出与个体患者因素的量身定制方法是必不可少的.
直接口服抗凝剂在特定的临床场景中适用于VTE预防.

结论:

准确的静脉瘤风险分层和个性化预防在多发性骨髓瘤管理中至关重要.
将风险模型与临床判断相结合,可以确保最佳的支持性护理.
需要进一步的研究和临床指导,以解决MM的VTE预防缺口.

关键词:

多发性骨髓瘤是一种多发性骨髓瘤.风险因素风险因素进行血栓预防治疗.血栓形成的原因之一是血栓形成.静脉血栓塞栓症是一种静脉血栓塞栓症.

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