TRIM38诱导在感染呼吸道同胞细胞病毒的细胞下调I型干扰素表达通过与TRIM25竞争,以结合RIG-I

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Qingqing Sun1,2, Xiao Han1,3, Lingtong Meng1

  • 1Department of Immunology, Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, Hebei, China.

Inflammation
|April 17, 2024
PubMed
概括

呼吸道同胞细胞病毒 (RSV) 感染上调TRIM25,激活RIG-I用于I型干扰素 (IFN-I) 生产. 然后TRIM38通过对抗TRIM25与RIG-I结合来抑制IFN-I,从而创建一个负反循环.

关键词:
国际货币基金组织-I在RIG-I中,RIG-I是指RIG-I.感染RNA病毒感染的RNA病毒感染.在 TRIM2525 中,在 TRIM38 里面,你会看到 TRIM38 的位置.

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