过渡性淋巴缺血症的临床影响
Luigi Petramala1, Cinzia Milito2, Francesca Sarlo3
1Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Clinical and experimental medicine
|April 17, 2024
概括
淋巴细胞减少,即淋巴细胞减少,在重症患者中很常见,在入院时影响了57%的患者. 持续的淋巴缺血影响预后,需要谨慎的患者管理.
科学领域:
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 免疫抑制会增加重症患者的发病率和死亡率.
- 淋巴缺血是免疫状况的一个关键指标.
研究的目的:
- 为了确定急诊室患者的淋巴缺血的患病率和持续性.
- 探索淋巴缺血症与患者特征/治疗之间的相关性.
主要方法:
- 招募了240名重症患者 (平均年龄75.1岁).
- 根据入院时的淋巴细胞计数对患者进行分类 (淋巴缺血与正常).
- 评估淋巴缺血持续到出院,分析淋巴细胞子集 (CD4 +,CD8 +,NK).
主要成果:
- 57%的患者在入院时出现了淋巴衰竭.
- 淋巴缺血患者年龄较大,65岁以上的患者比例更高.
- 所有的淋巴细胞子集都减少了;19%的患者患有持续的淋巴衰竭.
结论:
- 淋巴衰竭在重症患者中非常普遍.
- 持续的淋巴缺血症在显著的少数人中被观察到.
- 入院时的淋巴缺血是需要临床考虑的关键预后因素.
相关概念视频
Immunodeficiency Diseases
936
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
936
Disorders of Leukocytes
944
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
944
Cells of the Adaptive Immune Response
983
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
983
Pulmonary Tuberculosis I
242
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
242
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K


