在加拿大一项以人口为基础的病例控制研究中,环境多环芳暴露和乳腺癌风险
Patrick Hinton1, Paul J Villeneuve2, Elisabeth Galarneau3
1Department of Public Health Sciences, Queen's University, Kingston, ON, Canada.
Cancer causes & control : CCC
|April 17, 2024
概括
长期暴露于环境多环芳 (PAH),特别是,与加拿大更年期前乳腺癌的风险增加有关. 该研究发现,在绝经前的病例中存在显著的关联,但在绝经后的乳腺癌中结果不一致.
科学领域:
- 环境流行病学环境流行病学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 多环芳 (PAH) 是无处不在的环境污染物,具有已知的致癌性和内分泌干扰性.
- 在流行病学研究中对PAH暴露的人口水平建模是有限的.
- 甲是一种常见的城市PAH,也是其他PAH暴露的潜在指标.
研究的目的:
- 调查长期在住宅中暴露于环境PAHs,特别是,与乳腺癌风险之间的联系.
- 在加拿大的绝经前和绝经后妇女中单独评估这些关联.
主要方法:
- 基于全国人口的病例控制研究,使用加拿大的国家增强癌症监测系统 (NECSS).
- 使用基于20年住宅历史的GEM-MACH-PAH化学运输模型估计每年酸暴露量.
- 后勤回归分析用于计算几率比率 (OR) 和95%置信区间 (CI),控制混因素.
主要成果:
- 在安大略省和全国样本中,在兰暴露和绝经前乳腺癌之间发现了积极的关联.
- 对于绝经前乳腺癌,第二高暴露类别的调整后OR为2.48 (安大略省) 和1.59 (全国).
- 绝经后乳腺癌的相关性不一致,第二高暴露类别的OR为1.10 (安大略省) 和1.33 (全国);最高暴露水平无意义.
结论:
- 这项研究支持了暴露于环境PAHs增加了绝经前乳腺癌的风险的假设.
- 这些发现突显了环境污染物在乳腺癌病因学中的潜在作用.
- 可能需要进一步的研究来澄清PAHs在绝经后乳腺癌中的作用.
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