暴露与性别特异性甲状腺功能障碍有关:基于尿液和血液测量的两个独立横截面研究的一致证据
Ranqi Shao1, Liqin Su2, Peng Wang3
1China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing, 100050, China.
Biological trace element research
|April 17, 2024
概括
这项研究发现,较高的 (Cd) 暴露与较低的甲状腺刺激激素 (TSH) 和增加甲状腺功能障碍的风险有关. 这些关联是性别特定的,突出了潜在的环境健康问题.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 有限的基于人口的数据存在于 (Cd) 暴露和甲状腺功能,与相互矛盾的发现.
- 是一种有毒的重金属,具有已知的不良健康影响,但其对甲状腺健康的具体影响需要进一步阐明.
- 甲状腺功能障碍,以甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 的异常水平为特征,影响代谢过程和整体健康.
研究的目的:
- 通过在中国进行的两项独立的横截面研究,调查暴露与甲状腺功能障碍之间的关联.
- 探索含量与甲状腺功能标志物之间的关系中的潜在性别特异性.
- 为了确定与不同水平的生物标志物相关的甲状腺功能障碍风险.
主要方法:
- 在中国农村进行了两项独立的横截面研究,其中土壤中的含量各不相同.
- 甲状腺功能障碍的评估是基于甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 的血清水平.
- 统计分析包括多变量线性回归,多重逻辑回归和限制性立方线,以建模生物标志物 (尿液和血液) 与甲状腺功能之间的关联.
主要成果:
- 在这两项研究中,较高的水平始终与较低的TSH和增加甲状腺功能障碍风险有关.
- 在总参与者和男性中观察到尿和TSH之间的负相关性,而在女性中,血与TSH的负相关性.
- 尿液和血液中的含量升高与甲状腺功能障碍的更高风险显著相关 (分别为OR=1.77和OR=1.95).
结论:
- 暴露与特定性别的甲状腺功能障碍有关,这强调了针对性公共卫生干预的必要性.
- 这些发现表明,对甲状腺功能的影响是复杂的,并且可能因性别而异.
- 需要进一步的研究,以了解对甲状腺的内分泌干扰作用背后的机制.
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