辅酶Q10补充对血管内皮功能的影响:随机对照试验的系统审查和元分析
Shahrzad Daei1, Azam Ildarabadi1, Sima Goodarzi2
1Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
概括
辅酶Q10 (CoQ10) 补充剂通过剂量依赖的方式增加流媒扩展 (FMD) 来改善内皮功能. 这一元分析证实了CoQ10的存在.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 内皮功能研究 研究内皮功能研究.
背景情况:
- 辅酶Q10 (CoQ10) 正在研究其增强内皮功能的能力.
- 以前对辅酶Q10和内皮功能进行的临床试验产生了不一致的结果.
- 为了澄清CoQ10的影响,进行了系统审查和元分析.
研究的目的:
- 系统地审查和对辅酶Q10补充剂对内皮细胞因子的影响进行元分析.
- 评估CoQ10对流媒体扩大 (FMD),血管细胞粘附分子 (VCAM) 和细胞间粘附分子 (ICAM) 的影响.
主要方法:
- 在多个数据库中进行了全面的文献搜索,截至2023年7月19日.
- 量化数据的合成采用了一个随机效应模型,加权平均差异 (WMD) 和95%置信区间 (CI).
- 标准方法用于异质性评估,元回归,敏感性分析和出版偏差评估.
主要成果:
- 包含489名参与者的12项研究被纳入了元分析.
- 辅酶Q10补充剂显著增加了流媒体扩张 (FMD) (WMD: 1.45; 95% CI: 0.55 至 2.36; p < 0.02).
- 血管细胞粘附分子 (VCAM) 或细胞间粘附分子 (ICAM) 水平没有显著增加.
- 超回归表明CoQ10补充剂和口疾病变化之间存在剂量依赖的关联 (p = 0.006).
结论:
- 辅酶Q10补充剂以剂量取决的方式对口炎产生积极影响.
- 有证据表明,CoQ10在服用大约8周后就会影响口炎.
- 建议进行进一步的研究,以充分阐明CoQ10和内皮健康之间的关系.
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