在末期病患者中,左心室全球纵向应变和主要不良心血管事件发生之间的相关性分析
Jing Xie1, Xiaoli Long2, Jiwen Xie1
1Department of Ultrasound, The First People's Hospital of Lanzhou, No. 1, Wujiayuan, Jianlan Road Street, Qilihe District, Lanzhou, 730050, Gansu Province, China.
International urology and nephrology
|April 17, 2024
概括
减少左心室全球纵向应变 (LVGLS) 是末期病 (ESRD) 患者主要心血管不良事件 (MACE) 的关键预测因素. 较低的LVGLS表明12个月内MACE的风险更高.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管成像 - 心血管成像
背景情况:
- 末期病 (ESRD) 与心血管并发症的高风险有关.
- 左心室全球纵向应变 (LVGLS) 是心肌功能的一个新兴标志物.
- 在ESRD患者中LVGLS的预后价值需要进一步调查.
研究的目的:
- 调查LVGLS与ESRD患者发生重大心血管不良事件 (MACE) 的相关性.
- 确定LVGLS是否可以在这个人群中作为MACE的独立预测因子.
主要方法:
- 一组158名接受维持透析的ESRD患者进行了12个月的随访.
- 使用心声回声学测量LVGLS.
- 根据事件发生情况,患者被分为MACE和非MACE组.
主要成果:
- 在MACE组中观察到绝对LVGLS的降低,以及高灵敏度C反应蛋白 (hs-CRP) 和峰值素T (TNT) 的升高.
- 确定LVGLS (HR=1.06) 和hs-CRP (HR=1.17) 是MACE的独立预测因子.
- 对于MACE预测的ROC曲线下的面积为0.83,表明良好的区分能力.
结论:
- 减少LVGLS是12个月内在ESRD患者中MACE的显著独立风险因素.
- LVGLS作为ESRD中心血管事件的有价值的预后指标.
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