在对错误测量持续暴露的回归校准中对共变量进行因果选择
Wenze Tang1, Donna Spiegelman2,3, Xiaomei Liao1,4
1From the Department of Epidemiology, Harvard School of Public Health, Boston, MA.
研究人员可以通过仔细选择共变量来改善对连续暴露的测量误差的偏差调整. 调整暴露和结果的常见原因,以及测量错误和结果,对于准确的影响估计至关重要.
科学领域:
- 流行病学 流行病学
- 生物统计学 生物统计学
- 因果推理因果推理
背景情况:
- 回归校准在连续曝光中调整测量误差,但缺乏对共变量选择的指导.
- 测量误差可以在观察性研究中对影响估计产生偏差.
- 现有的方法不能全面地解决测量错误和结果模型中的共变量选择.
研究的目的:
- 在因果推理框架下为回归校准选择最小和高效的共变量调整集提供指导.
- 确定哪些共变量在测量误差和结果模型中是必不可少的,以解决测量误差带来的偏差.
- 为了将回归校准扩展到允许效果修改的非参数设置.
主要方法:
- 利用因果推理框架来研究回归校准的共同变量选择.
- 在真实暴露和结果的常见原因,测量错误和结果的常见原因,预后变量和仅与真实暴露相关的共同变量之间进行区分.
- 将拟议的共变量选择方法应用于卫生专业人员随访研究数据集.
主要成果:
- 确定真实暴露/结果和测量错误/结果的常见原因必须在测量错误和结果模型中进行调整.
- 证明结果模型中的预后变量调整可以提高效率.
- 显示,仅与真实暴露相关的协变量进行调整通常会导致效率损失.
结论:
- 为回归校准中选择共变量提供了一个因果框架,以准确地调整测量误差.
- 拟议的方法通过指导共变量选择,确保了高效和公正的效应估计.
- 该研究扩展了回归校准,以允许以非参数的方式通过共变量修改效应.
更多相关视频
06:55Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
10:33Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
Published on: September 4, 2017
相关概念视频
Calibration Curves: Linear Least Squares
For data that follow a straight line, the standard method for fitting is the linear...
Strategies for Assessing and Addressing Confounding
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
Multiple Regression
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
Censoring Survival Data
Mechanistic Models: Compartment Models in Individual and Population Analysis
Criteria for Causality: Bradford Hill Criteria - II
