发展精密瘤学药物的评估途径,以改善患者的获取:一种无瘤透镜
Priscila Radu1, Gayathri Kumar1, Amanda Cole1
1Office of Health Economics, London, United Kingdom.
The oncologist
|April 17, 2024
概括
精确瘤学 (PO) 和瘤不可知疗法 (TA) 提供有针对性的癌症治疗,但由于评估挑战,获得限制. 建议采用生命周期方法和利益相关方的合作,以改善患者获得这些创新药物的机会.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 药物经济学 药物经济学
背景情况:
- 基因组和分子改变在癌症诊断和治疗中至关重要.
- 精密瘤学 (PO) 使用基因组资料进行量身定制的治疗,旨在减少副作用并获得更好的结果.
- 在PO中的瘤不可知性 (TA) 疗法针对特定的基因组变化,无论瘤的起源如何,但面临着进入障碍.
研究的目的:
- 确定评估精确瘤学和瘤不可知药物的挑战.
- 探索这些评估挑战的潜在解决方案.
- 为这些疗法的代生命周期评估提供建议.
主要方法:
- 文献审查以确定当前的挑战和机遇.
- 通过采访与主要利益相关者和欧洲专家进行定性数据收集.
- 通过行业研讨会和国际专家委员会会议建立专家共识.
主要成果:
- 许多挑战阻碍了对PO和TA药物的评估和可访问性,用现实世界的例子说明了这一点.
- 提出了一种生命周期评估方法,包括证据生成,监管/报销策略和支付/收养解决方案.
- 应对这些挑战需要利益相关者共同承担责任,以最大限度地提高PO药物的价值.
结论:
- 扩大对综合基因组测试的获取,以获得更广泛的患者利益.
- 培养一个学习的医疗保健系统,以整合新的证据和治疗方法.
- 确保快速,公平地获得具有成本效益的精密瘤治疗,以改善患者的治疗结果.
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