域安排的重大变化与白的进化有关
Alina A Mikhailova1, Elias Dohmen1, Mark C Harrison1
1Institute for Evolution and Biodiversity, University of Münster, Münster, Germany.
Journal of evolutionary biology
|April 17, 2024
概括
蛋白质域的重新排列,而不是新的基因,推动了白社会性的进化. 蛋白质结构的这些变化使得功能性新性成为可能,导致白中的专业化种姓和复杂社会.
科学领域:
- 进化生物学 进化生物学
- 基因组学就是基因组学.
- 分子生物学分子生物学
背景情况:
- 欧社会性是一种复杂的特征,涉及无菌种类,在白 (Blattodea) 与海门类相比,它们的进化方式不同.
- 长的社会性源于减少蛋白质体大小,质疑功能新性的来源.
研究的目的:
- 调查蛋白质域重组在白社会化的演变中的作用.
- 了解现有蛋白质如何实现功能性新性.
主要方法:
- 单独的和eusocial白的比较蛋白质组分析.
- 在Blattodea族系中推断了超过5,000个域名重排.
- 确定了白起源的新领域安排及其功能.
主要成果:
- 90种虫起源的新型域安排,富含与长寿相关的功能 (例如蛋白质平衡,DNA修复).
- 与发展途径和种姓的出现相关的域名重组.
- 在复杂的社会中,与蛋白质糖化和离子运输相关的110个额外的重组.
- 重组的基因显示出种姓偏见的表达/拼接以及增加的DNA甲基化.
结论:
- 蛋白质域的重新排列对于在白社会化的进化过程中产生功能新性至关重要.
- 这些重组促进了专门的种姓和复杂的社会结构的发展.
- 重组基因与非重组基因之间存在着根本的监管差异.
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