在中度至深度镇静期间使用连续输注雷米马佐拉姆的呼吸暂停,与普罗波福和德克斯梅德托米丁相比:一项追溯观察性研究
Chahyun Oh1,2, Jiyong Lee1,2, Jieun Lee1
1Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, Korea.
在区域麻醉期间的雷米马佐拉姆和普罗波镇静显示出较高的呼吸暂停率与德克斯米德米丁相比. 在使用雷米马佐拉姆治疗中度至深度镇静时,仔细的呼吸监测至关重要.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 雷米马佐拉姆在区域麻醉期间为镇静提供了快速开始和抵消.
- 它的呼吸安全概况,特别是连续输注时,需要进一步调查.
- 与已建立的镇静剂 (如普罗波福和德克斯梅德托米丁) 进行比较的数据有限.
研究的目的:
- 为了比较remimazolam连续输液期间呼吸暂停的发病率与区域麻醉后中度至深度镇静时的propofol和dexmedetomidine.
- 在这种临床环境中评估雷米马佐拉姆的呼吸安全性.
主要方法:
- 一项回顾性研究分析了634名在区域麻醉下接受骨科手术的患者.
- 患者通过连续输注雷米马佐拉姆 (R组),普罗波 (P组) 或德克斯梅德托米丁 (D组) 接受了中度至深度镇静.
- 倾向性得分加权的多变量逻辑回归被用来比较跨组的呼吸暂停发病率 (>10秒).
主要成果:
- 雷米马佐拉姆的呼吸暂停发病率为63.9%,普罗波的发病率为67.3%,德克斯梅德托米丁的发病率为48.5%.
- 与德克斯梅托米丁相比,雷米马佐拉姆 (2.33) 和普罗波 (2.50) 的呼吸暂停率明显高于德克斯梅托米丁.
- 该研究强调,在建议剂量下,雷米马佐拉姆与呼吸暂停相关的大量率.
结论:
- 连续输注雷米马佐拉姆,类似于普罗波,在中度至深度镇静后区域麻醉时,与呼吸暂停的高发病率有关.
- 德克斯梅德托米丁表明,呼吸暂停的发生率相对较低.
- 密切的定位和警的呼吸监测对于接受雷米马佐拉姆镇静剂的患者至关重要.
更多相关视频
14:52Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
Published on: January 13, 2018
08:49Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
相关概念视频
Parenteral Anesthetics: Overview
Stages of General Anesthesia
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Inhalational Anesthetics: Overview
Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
