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Updated: Jun 28, 2025

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多发性硬化症患者的胰岛素样生长因子-1 (IGF-1) 水平:系统性审查和元分析

Shirin Yaghoobpoor1, Mobina Fathi1, Kimia Vakili1

  • 1Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PloS one
|April 17, 2024
PubMed
概括

这次元分析发现,在多发性硬化症 (MS) 患者和健康对照者之间,胰岛素样生长因子-1 (IGF-1),生长激素 (GH),或IGF结合蛋白-2 (IGFBP-2) 和IGFBP-3水平没有显著差异,IGFBP-1除外. 在MS患者中,IGFBP-1的血液水平显著更高.

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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