高骨周转率的老年男性的骨微架构迅速下降 - - 前性STRAMBO研究
Pawel Szulc1, Danielle E Whittier2, Steven K Boyd2
1INSERM UMR 1033, University of Lyon, Hôpital Edouard Herriot, Lyon 69437, France.
概括
高年龄的男性具有高的骨周转率,经历了加速的骨损失. 较高的骨循环标志物,如CTX-I和tDPD,预测骨微架构和骨强度在8年内下降得更快.
科学领域:
- 老年学是一门学科.
- 骨生物学 骨生物学 骨生物学
- 代谢性骨疾病 代谢性骨疾病
背景情况:
- 老年男性的骨质损失和微型结构恶化加快.
- 高骨周转率与骨折风险增加有关.
- 了解骨循环标记 (BTM) 的预测价值对于管理老年男性骨健康至关重要.
研究的目的:
- 为了研究基线骨循环标志物与老年男性随后的骨微型架构下降之间的关联.
- 为了确定特定的BTM是否能预测骨损失的速度和骨强度的恶化.
主要方法:
- 在8年内对825名60-87岁的男性进行了长度研究.
- 在基线测量血清BTMs (骨素,骨酸酶,PINP,CTX-I) 和尿液tDPD.
- 高分辨率的外围定量计算断层扫描 (pQCT) 评估了远半径和骨的骨微型结构和强度.
主要成果:
- 较高的CTX-I和tDPD基线水平与骨矿物密度,皮质厚度和骨强度在两个骨部位的更快下降有关.
- 骨质素和骨性酸酶的升高也预测了骨矿物质密度和强度的加速丧失.
- 一个复合的BTM得分表明,在最高四分位数的男性经历了显著更大的皮质骨和骨强度的损失,与最低四分位数的男性相比.
结论:
- 基线骨周转标记物,特别是CTX-I和tDPD,是老年男性骨微架构和力量下降的显著预测因素.
- 高骨周转率,如 elevated BTMs 所示,与 8 年内骨损失和骨强度降低的速度相比快得多.
- 这些发现凸显了BTM在识别老年男性的实用性,这些老年男性有更高的骨恶化和潜在骨折风险.
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