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膀癌治疗研究的临床前模型

Iris Ertl¹, Shahrokh F Shariat^{1,2,3,4,5,6,7}, Walter Berger⁸

¹Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

Current opinion in urology

|April 17, 2024

概括

膀癌 (BC) 研究的近期进展已经产生了临床前模型,如患者衍生器官和异种移植. 这些模型密切模仿瘤生物学,有助于开发针对不同BC亚型的向疗法.

科学领域:

在瘤学瘤学.
翻译研究是翻译研究.
癌症生物学癌症生物学

背景情况:

膀癌 (BC) 是一种异质性疾病,对开发有效治疗提出了挑战.
临床前模型对于了解BC亚型和确定向疗法至关重要.

研究的目的:

审查最近在开发膀癌临床前模型方面的进展.
要突出模拟各种BC瘤体内特征的模型.

主要方法:

专注于患者衍生器官 (PDO) 和患者衍生异种移植 (PDX).
在免疫能力强的宿主中评估合成体内活体模型.

主要成果:

PDO和PDX有效地回顾了原始瘤的分子,组织病理和药物反应概况.
辛根基模型对于开发免疫疗法和研究免疫系统相互作用是有价值的.

结论:

在过去的两年中,新的体外和体外模型已经开发出来.
这些模型密切地复制了人类膀瘤的生物学和异质性,支持药物开发和个性化医学.

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