偏头痛和没有偏头痛的人在皮层形态上的差异:偏头痛的注册表 (REFORM) MRI研究
Rune H Christensen1, Håkan Ashina1, Haidar M Al-Khazali1
1From the Department of Neurology (R.H.C., H.A., H.M.A.-K., A.H.P., F.M.A., M.A.), Danish Headache Center, Copenhagen University Hospital-Rigshospitalet; Department of Clinical Medicine (R.H.C., H.A., H.M.A.-K., F.M.A., M.A.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Harvard Medical School (R.H.C., H.A., H.M.A-K.), Boston, MA; Department of Anesthesia, Critical Care and Pain Medicine (R.H.C., H.A., H.M.A-K.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Brain and Spinal Cord Injury (H.A., F.M.A.), Copenhagen University Hospital-Rigshospitalet, Denmark; Department of Neurology (Y.Z.), The First Affiliated Hospital of Chongqing Medical University, China; Department of Radiology (D.T.), Rigshospitalet Glostrup, Denmark; Translational Imaging in Neurology (ThINk) Basel (A.C., C.G.), Department of Biomedical Engineering, University Hospital Basel, University of Basel; Neurologic Clinic and Policlinic (A.C., C.G.), MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Switzerland; Gillberg Neuropsychiatry Centre (N.H.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden; Athinoula A. Martinos Center for Biomedical Imaging (N.H.), Massachusetts General Hospital, Boston; and Danish Knowledge Center on Headache Disorders (M.A.), Glostrup, Denmark.
偏头痛与参与疼痛处理的大脑区域持续的皮质变化有关,特别是在慢性偏头痛患者中. 胰岛和前带皮层的这些结构差异表明长期适应这种情况.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 大脑解剖学 大脑解剖学
背景情况:
- 偏头痛是一种神经系统疾病,其特点是反复出现的头痛.
- 结构神经成像可能会揭示由于慢性疼痛而导致的偏头痛患者的大脑适应.
- 皮层形态测量为这些潜在适应提供了洞察力.
研究的目的:
- 为了比较偏头痛和健康对照个体之间的皮质形态测量.
- 为了研究偏头痛亚型之间皮质形态的差异.
主要方法:
- 一组296名偏头痛患者和155名健康对照人接受了3TMRI.
- 使用FreeSurfer分析皮质表面积,厚度和体积.
- 统计比较根据年龄,性别和总内体积进行了调整.
主要成果:
- 与对照人群相比,偏头痛患者在左侧胰岛的皮质表面积减少.
- 慢性偏头痛患者的左侧胰岛表面积减少,右尾前带皮层表面积增加.
- 对于偏头痛与光环或偏头痛在头痛期间的偏头痛,没有发现显著的差异.
结论:
- 偏头痛与疼痛处理区域 (如胰岛和前带皮层) 的持续结构变化有关.
- 这些皮层变化在患有慢性偏头痛的个体中最为明显.
- 这些发现表明,偏头痛导致特定大脑区域的持久适应.
相关概念视频
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