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心血管风险增加和 Prurigo nodularis 的死亡率:全球队列研究

Henning Olbrich¹, Khalaf Kridin², Gema Hernández³

¹Department of Dermatology, University of Lübeck, Lübeck, Germany.

|April 17, 2024

概括

结节炎 (PN) 显著增加心脏和血管疾病的风险,以及死亡率. 早期识别和管理对于PN患者至关重要.

科学领域:

心脏病学心脏病学
皮肤病学皮肤病学
流行病学流行病学

背景情况:

发结节 (PN) 是一种慢性皮肤疾病,其特征是强烈的结节.
虽然PN主要是皮肤性,但与糖尿病和慢性功能衰竭等全身性疾病有关.
以前的研究表明PN与心血管疾病之间存在关联,但有局限性.

研究的目的:

为了调查诊断出 Prurigo nodularis 的患者心脏和血管疾病和死亡率的风险.
评估dupilumab治疗对这些风险的影响.

主要方法:

对64,801名PN患者和匹配的对照组的电子健康记录 (EHR) 的回顾性分析.
倾向匹配用于控制混因素.
分分析检查了根据性别,种族和治疗方式分层的风险.

主要成果:

前列腺不全的诊断与急性心脏事件的显著更高风险有关,包括心力衰竭和心肌梗塞 (HR 1.11).
在PN患者中,全因死亡率较高.
在PN诊断后观察到慢性血管疾病 (例如,外周动脉疾病) 和结构性心脏病的患病率增加.
白人和女性患者的风险更明显.
与其他全身疗法相比,杜皮卢马布治疗显示死亡风险略有降低,但心血管疾病风险没有降低.

结论:

结是发展广泛的心脏和血管疾病的重要危险因素,并与死亡率增加有关.
医疗保健提供者在治疗PN患者时应考虑这些心血管和死亡风险.

关键词:

心血管疾病是什么心血管疾病死亡率死亡率死亡率心肌梗塞的心脏病发作皮结节 (prurigo nodularis) 是一种引起皮的疾病.一次性中风,中风.在TriNetXX中,我们有了三网.

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