Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

7.2K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
7.2K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.7K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.7K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

6.7K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
6.7K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.6K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.6K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

2.3K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.3K
Cell Migration01:09

Cell Migration

17.0K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Tissue mechanopathology of cancer.

Developmental cell·2026
Same author

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity.

Nature communications·2026
Same author

Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights.

The Journal of pathology·2026
Same author

Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling.

The Journal of clinical investigation·2026
Same author

Adhesion-derived condensates control component availability to regulate adhesion dynamics.

Nature communications·2026
Same author

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton.

Nature materials·2026

相关实验视频

Updated: Jun 28, 2025

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

12.6K

研究细胞-ECM相互作用,细胞粘附动态和迁移的新型工具.

Michal Dibus1, Omkar Joshi1, Johanna Ivaska2

  • 1Turku Bioscience Centre, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland.

Current opinion in cell biology
|April 17, 2024
PubMed
概括

新的方法加强了细胞-细胞外矩阵 (ECM) 粘附的研究,超越2D到3D系统,并利用超分辨率成像来更深入地了解细胞行为和组织完整性.

更多相关视频

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

11.0K
Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence
14:55

Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence

Published on: March 5, 2022

4.0K

相关实验视频

Last Updated: Jun 28, 2025

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

12.6K
Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

11.0K
Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence
14:55

Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence

Published on: March 5, 2022

4.0K

科学领域:

  • 细胞生物学 细胞生物学
  • 生物物理学的生物物理.
  • 生物材料科学 生物材料科学

背景情况:

  • 集成因介导的细胞粘附对于基本的细胞过程至关重要,如迁移,机械转导和维持组织完整性.
  • 来自细胞外基质 (ECM) 的物理化学线索,包括组成,刚性和拓,在体内复杂地调节这些粘附过程.
  • 现有的研究方法往往难以复制体内条件的复杂性,限制了对细胞-ECM相互作用的全面理解.

研究的目的:

  • 审查研究细胞-细胞外矩阵 (ECM) 粘附的最近的方法进步.
  • 介绍一套技术的"工具箱",预计将推动未来的细胞粘附研究.
  • 为了弥合体外实验设置和体内生理条件之间的差距.

主要方法:

  • 讨论方法上的突破,使从二维基板转向更复杂的三维系统.
  • 突出了超高分辨率成像技术的进步,以对粘附纳米结构进行详细分析.
  • 选定的方法与相关的生物发现一起示例化,以证明适用性.

主要成果:

  • 确定关键的方法创新,以促进细胞-ECM粘附的研究.
  • 展示先进技术如何为粘附纳米结构和细胞行为提供更深入的见解.
  • 通过将新方法应用于细胞粘附研究中的重要生物问题来验证新方法.

结论:

  • 编制的先进方法工具箱为体外研究提供了更准确的近似体内条件.
  • 这些增强的方法有望加深我们对涉及细胞-ECM粘附的生理和病理生理过程的理解.
  • 未来的细胞粘附研究将从采用这些复杂和动态的实验方法中获益.