相关实验视频

Updated: Jun 28, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

在全身性硬化症中,明显和亚临床的左心室缩功能障碍的预后和功能重要性

Jessica L Fairley¹, Dylan Hansen², Susanna Proudman³

¹Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia; Department of Rheumatology, St. Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

Seminars in arthritis and rheumatism

|April 17, 2024

概括

系统性硬化症 (SSc) 可以导致心脏功能障碍,影响生存和身体功能. 早期发现微妙的左心室全球纵向应变 (LV-GLS) 损伤对于管理SSc患者至关重要.

科学领域:

心脏病学心脏病学
类风湿病学类风湿病学
系统性硬化症研究研究

背景情况:

系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,可能涉及到心脏.
左心室 (LV) 功能障碍可能发生在SSc患者中,影响预后.
在SSc中量化LV功能障碍的患病率和临床影响至关重要.

研究的目的:

为了确定左心室 (LV) 功能障碍在全身性硬化症 (SSc) 患者的频率.
调查SSc相关的LV功能障碍的临床影响和预后价值.
评估 LV 损伤的明显和亚临床形式.

主要方法:

来自澳大利亚硬化皮肤症队列研究的数据分析.
包括符合ACR/EULAR标准的SSc患者与心声回声 LVEF测量.
排除 LV 功能障碍的次要原因;评估 LV 喷射率 (LVEF) 和 LV 全面纵向应变 (LV-GLS).
统计分析包括千二测试,t测试,威尔科克森等级和测试,GEE,卡普兰-梅尔和考克斯比例危险模型.

主要成果:

2.4%的SSc患者的LVEF<50%,而0.6%的LVEF≤40%.
在21%正常LVEF (≥50%) 的患者中检测到LV-GLS受损.
无论是LVEF<50%还是LV-GLS受损都与死亡率增加和生存率降低有关.
LV 功能障碍与呼吸障碍增加,运动能力降低和生活质量恶化相关.

结论:

露面和亚临床LV功能障碍是SSc.的重大并发症.
在正常的LVEF患者中,LV-GLS受损表明缺乏认可的系统功能障碍负担.
这些发现强调了在SSc管理中评估LV功能的重要性,以改善患者的治疗结果.

关键词:

左心室功能障碍是什么结核病心脏参与结核病幸存的生存方式系统性硬化症系统性硬化症

更多相关视频

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

相关概念视频

Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

Imbalances in Cardiac Output

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...