在伊朗人口中与延长QTc间隔相关的因素:MASHAD队列研究
Toktam Sahranavard1, Sara Saffar Soflaei2, Rasoul Alimi3
1International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal of electrocardiology
|April 17, 2024
概括
延长QTc间隔与老年,高胆固醇血症,高血压和2型糖尿病有关. 风险因素在男性和女性之间有所不同,男性也与焦虑和抑郁有关.
科学领域:
- 心脏病学 心脏病学
- 临床电生理学 临床电生理学
- 公共卫生 公共卫生
背景情况:
- 延长QTc间隔是一个重要的全球健康问题,与潜在的致命性心律失常有关,如Torsades de Pointes.
- 识别风险因素对于有效的预防和管理战略至关重要.
研究的目的:
- 调查与男性和女性QTc间隔延长相关的风险因素.
- 在针对性干预中区分性别之间的风险因素概况.
主要方法:
- 利用了马什哈德中风和心脏动脉样硬化障碍 (MASHAD) 队列研究的数据.
- 采用Bazett的公式来纠正QT区间的心率.
- 进行了单变量和多变量顺序逻辑回归分析,以确定QTc延长的独立风险因素.
主要成果:
- 该研究包括8878名参与者 (5318名女性,3560名男性),年龄在35-65岁之间.
- QTc延长与老年,高胆固醇血,高血压 (HTN) 和2型糖尿病 (T2DM) 以及较低的体力活动有关.
- 男性的独立风险因素包括年龄,高胆固醇血症,HTN,T2DM,严重焦虑和轻度抑郁症. 对于女性来说,只有HTN和T2DM是独立的风险因素.
结论:
- 老年,高胆固醇血症,HTN,T2DM,严重焦虑和轻度抑郁症与男性QTc延长的风险增加有关.
- 已确定HTN和T2DM是女性QTc延长的独立风险因素.
- 医疗保健提供者应对这些风险因素保持警,以积极主动地管理患者.
相关概念视频
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
988
Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
988
Electrocardiogram
2.3K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
2.3K
Factors Influencing Heart Rate
2.6K
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
2.6K
Decreased pulse rate
541
Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
541


