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Updated: Jun 28, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
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生物膜伪装纳米粒子:在向药物输送系统中发生了范式转变

Saba Asif Qureshi1, Km Rafiya1, Sakshi Awasthi2

  • 1Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.

Colloids and surfaces. B, Biointerfaces
|April 17, 2024
PubMed
概括

生物模拟膜涂层纳米粒子为精密医学提供先进的向药物输送. 这些生物相容系统在治疗应用中显示出提高疗效和减少副作用的潜力.

关键词:
生物模拟学是一种生物模拟学.排毒 排毒 排毒 排毒伪装在混合细胞膜上的NP用膜伪装的NP可以被伪装.有针对性的交付目标.

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相关概念视频

Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
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Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
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