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在癌症免疫疗法中调节肠道微生物群:利用微生物来提高治疗疗效

Xing Kang¹, Harry Cheuk-Hay Lau², Jun Yu²

¹Institute of Digestive Disease, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, Hong Kong; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Cell reports. Medicine

|April 17, 2024

概括

肠道微生物组显著影响癌症免疫疗法的有效性和副作用. 像便微生物群移植和益生菌这样的策略显示,通过向这些微生物来改善患者的治疗结果是有希望的.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
微生物组研究微生物组研究

背景情况:

癌症免疫疗法提供了一个有前途的治疗途径,但患者的反应有很大差异.
免疫相关的不良事件和低于最佳的疗效需要新的治疗策略.
人们越来越认识到肠道微生物对癌症治疗结果的影响.

研究的目的:

探索肠道微生物及其代谢物在癌症免疫治疗中的作用.
审查针对微生物组的策略,以提高免疫疗法的疗效.
讨论这个领域当前的挑战和未来的方向.

主要方法:

关于研究肠道微生物群对癌症免疫治疗的影响的文献综述.
对宿主微生物相互作用和所涉及的代谢途径的分析.
评估微生物组调节干预措施,如便微生物群移植,益生菌和饮食改变.

主要成果:

肠道微生物组的组成和功能与免疫疗法反应和毒性相关.
微生物代谢物,包括短链脂肪酸和托代谢物,调节抗瘤免疫力.
针对微生物组的干预措施显示出改善治疗疗效的潜力.

结论:

肠道微生物组是影响癌症免疫治疗结果的关键因素.
调节肠道微生物组提供了一个有希望的策略,以提高治疗效率和减轻不良事件.
需要进一步的研究来克服挑战并优化癌症患者的基于微生物组的治疗方法.

关键词:

免疫疗法免疫疗法代谢产物的代谢产物微生物组是一个微生物组.针对微生物组的方法.

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