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阻塞性睡眠呼吸暂停和静脉血栓塞栓症之间的关联:双向的双样本孟德尔随机化研究

Zhihai Huang¹, Zhenzhen Zheng², Lingpin Pang¹

¹Emergency Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.

Thrombosis and haemostasis

|April 17, 2024

概括

这项研究没有发现阻塞性睡眠呼吸暂停 (OSA) 和静脉血栓栓塞 (VTE),包括肺栓塞 (PE) 和深静脉血栓塞 (DVT) 之间的遗传联系. 门德尔的随机化分析证实,这两个方向之间没有因果关系.

科学领域:

心血管研究研究心血管研究
睡眠医学睡眠医学
遗传学遗传学是一个

背景情况:

观察性研究表明阻塞性睡眠呼吸暂停 (OSA) 和静脉血栓塞栓症 (VTE) 之间存在联系,但研究结果不一致.
这种争议需要进一步调查OSA和VTE之间的潜在因果关系.

研究的目的:

使用遗传数据调查阻塞性睡眠呼吸暂停 (OSA) 和静脉血栓塞栓症 (VTE) 之间的潜在因果关系.
探索两方面的关系:OSA影响VTE风险和VTE影响OSA风险.

主要方法:

使用双向的双样本孟德尔随机化 (MR) 分析.
利用来自欧洲人口的大规模全基因组关联研究的总结级数据.
除了敏感性分析外,还使用了逆方差加权,MR-Egger,加权中位数和MR-PRESSO方法.

主要成果:

基因预测阻塞性睡眠呼吸暂停 (OSA) 对静脉血栓塞栓症 (VTE) 的风险没有显著影响,包括肺栓塞 (PE) 和深静脉血栓症 (DVT).
反向门德尔随机化分析也没有发现VTE和OSA之间存在关联的实质证据.
敏感性分析和补充的MR方法证实了主要的发现.

结论:

该研究发现没有遗传证据支持阻塞性睡眠呼吸暂停 (OSA) 和静脉血栓塞栓症 (VTE) 之间的显著关联.
双向门德尔随机化分析表明,OSA和VTE在任何方向之间都没有因果关系.

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