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和多基物质与非酒精性脂肪肝疾病之间的关联:中国西北部的一项嵌套病例对照研究

Yuanqin Wu¹, Zhiyuan Cheng², Wei Zhang³

¹Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, PR China.

Environmental pollution (Barking, Essex : 1987)

|April 17, 2024

概括

暴露于和多基物质 (PFAS) 与非酒精性脂肪肝疾病 (NAFLD) 的风险有关. 这项研究调查了特定的PFAS化合物与NAFLD发病率之间的流行病学联系.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
流行病学流行病学

背景情况:

和多醇基物质 (PFAS) 是广泛使用的化学物质,具有已知的肝毒性作用.
PFAS暴露与非酒精性脂肪性肝病 (NAFLD) 患病率之间的关联仍然不清楚.
了解这种联系对于公共卫生至关重要,因为PFAS的广泛暴露.

研究的目的:

调查特定PFAS的血清度与NAFLD的流行率之间的流行病学联系.
评估与单次和同时暴露于PFAS混合物相关的NAFLD风险.
为了确定特定的PFAS化合物驱动观察到的关联.

主要方法:

使用金队列 (2014-2019) 的数据,采用了一个嵌套病例控制研究设计.
血清PFAS度使用高性能液体染色学-并联质谱法 (HPLC-MS/MS) 来量化.
条件后勤回归,量子g计算 (QgC) 和贝叶斯内核机器回归 (BKMR) 模型被用于分析关联.

主要成果:

包括PFPeA,PFOA和9Cl-PF3ONS在内的PFAS与NAFLD发病率呈正相关性.
PFNA,PFHxS和PFOS与NAFLD发病率呈现出非线性负相关性.
观察到PFAS混合物对NAFLD发病的显著联合作用 (OR:1.52,95%CI:1.24,1.88),其中PFPeA和9Cl-PF3ONS推动了正相关性,PFNA和PFOS影响了负相关性.

结论:

对PFAS的个人和共同暴露与NAFLD的风险增加有关.
特定的PFAS化合物如PFPeA,PFOA和9Cl-PF3ONS与较高的NAFLD风险有关.
该研究强调了PFAS混合物和NAFLD之间的复杂关系,表明了PFOS和PFNA等化合物之间的潜在相互作用.

关键词:

BKMR BKMR 在线播放事件发生率事件发生率非酒精性脂肪性肝病是什么?在QgC中,QgC是QgC.对于每种和多种醇基物质.

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