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Cefixime装载裸体和功能化化化纳米载体及其生物医学应用

Deepak Verma¹, Manunya Okhawilai², Karthik Subramani³

¹International Graduate Program of Nanoscience and Technology, Graduate School, Chulalongkorn University, Bangkok, 10330, Thailand.

Environmental research

|April 17, 2024

概括

哈洛西特纳米管 (HNTs) 有效地提供抗生素cefixime (CFX). 修改后的HNT显示药物加载和持续释放的增强,提供了改善抗菌疗法的潜力,降低了细胞毒性.

科学领域:

纳米医学和药物输送
材料科学材料科学材料科学
生物技术是生物技术.

背景情况:

有效的药物输送对于疾病恢复至关重要.
纳米载体为控制,向和持续的药物释放提供了先进的解决方案.
粘土矿物质正在成为具有低细胞毒性的有希望的生物相容纳米载体.

研究的目的:

为了利用Halloysite纳米管 (HNTs) 作为纳米载体用于Cefixime (CFX) 输送.
用硫酸和APTES功能化HNT,以增强药物加载和释放.
为了比较分析装载CFX的裸体,酸处理和APTES处理的HNT的性能和性能.

主要方法:

通过硫酸和APTES,Halloysite纳米管 (HNT) 得到了功能化.
塞菲西 (CFX) 被装载到裸体,酸处理和APTES处理的HNT中.
描述包括XRD,FT-IR,TEM,BET,TGA,吸附研究,磁盘扩散和MTT测试.

主要成果:

具有APTES功能化的HNT显示出最高的CFX封装效率 (53.43%).
药物载荷的HNT显示出显著的抗菌活性和降低细胞毒性.
与其他配方相比,APTES-CFX-HNTs显示持续释放cefixime.

结论:

功能化的Halloysite纳米管是有效的纳米载体,用于传递cefixime.
修改APTES可以增强药物加载并促进持续的药物释放.
这些发现表明,使用修改后的HNTs可以改善抗生素治疗的潜力.

关键词:

吸附性研究的研究.抗菌性质抗菌性质这就是Cefixime的意思.细胞活力细胞活力药物释放药物释放的时间在Halloysite纳米管 (HNT) 中.

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