前额前 - 脑下垂体甲基信号传递在冲突处理过程中介导延迟反应
Jeong Woo Choi1, Mahsa Malekmohammadi2, Soroush Niketeghad2
1Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.
中间额叶皮层 (MFC) 监测冲突,并向亚thalamic核 (STN) 发出信号以抑制行动. 这些大脑区域与运动皮质 (M1) 相互作用,在冲突期间调节运动.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 发动机控制器的控制器
背景情况:
- 中间前额皮质 (MFC) 与冲突监测有关,而亚thalamic核 (STN) 与行动抑制有关.
- 在冲突期间,了解MFC,STN和运动皮层 (M1) 之间的综合时空和光谱相互作用是有限的.
研究的目的:
- 在冲突监测和行动调节期间,研究前补充运动区 (preSMA),M1,STN和内球 (GPi) 之间的神经动态和相互作用.
- 阐明和β振荡在冲突下调解运动行为的作用.
主要方法:
- 在20名患有帕金森氏症或 dystonia 经历深度大脑刺激手术的患者中进行了内神经记录.
- 患者执行了侧面任务,同时从preSMA,M1,STN和GPi记录神经信号.
主要成果:
- 冲突导致theta功率从preSMA到STN到M1的连续增加,运动延迟与STNtheta功率相关.
- 从STN传输到M1之前,从M1到GPi的β流量增加,表明作用抑制.
- 截然不同的theta (冲突相关) 和beta (运动相关) 网络以动态相互作用来调节运动性能.
结论:
- 预SMA作为冲突监测的MFC区域,向STN发出信号,启动"制动"机制.
- 冲突期间的行动调节涉及并行互动的theta和beta网络,在空间,光谱和时间上分开.
- 这些发现凸显了冲突期间底层的运动控制和行动抑制的复杂神经电路.
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