在随机试验组中评估出版物完整性的统计技术:叙述性综述
Mark J Bolland1, Alison Avenell2, Andrew Grey3
1Department of Medicine, University of Auckland, Private Bag 92 019, Auckland 1142, New Zealand; Department of Endocrinology, ADHB, Private Bag 92 024, Auckland 1142, New Zealand.
统计工具可以评估随机对照试验 (RCT) 的出版完整性. 这些方法比较基线变量分布,以检测RCT组中潜在的数据制造.
科学领域:
- 生物统计学 生物统计学
- 临床试验方法论 临床试验方法论
- 研究诚信研究诚信
背景情况:
- 评估随机对照试验 (RCT) 的完整性对于可靠的证据综合至关重要.
- 出版偏见和数据制造可能会损害研究结果的有效性.
研究的目的:
- 审查和描述用于评估RCT组的出版完整性的统计工具.
- 突出这些工具在检测潜在的研究不当行为的有用性.
主要方法:
- 对现有统计方法的叙述性审查.
- 专注于工具比较观察到与预期的基线变量分布在RCT.
主要成果:
- 对于连续和分类基线变量存在统计工具.
- 这些工具分析平均值,P值,标准偏差和频率计数.
- 这些工具在识别出版物完整性问题和歧视伪造数据方面已经证明有效.
结论:
- 统计工具提供了一种有价值的方法来评估RCT组的出版完整性.
- 这些工具可以应用于系统审查,调查研究不当行为和手稿选.
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