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开发一种方法来评估外部环境对指甲药物稳定性的影响,使用微细分分析

Kenji Kuwayama¹, Hajime Miyaguchi¹, Tatsuyuki Kanamori¹

¹National Research Institute of Police Science, Chiba, Japan.

Drug testing and analysis

|April 17, 2024

概括

指甲药物测试受到手部护理产品的影响. 一种新的微细分分析方法显示了化品和肥如何影响指甲中的药物稳定性,有助于法医毒理学.

科学领域:

法医毒理学法医毒理学
分析化学分析化学
皮肤病学皮肤病学

背景情况:

爪子为回顾性药物使用分析提供了头发的替代品.
每天的手和指甲护理实践可能会损害指甲内的内部药物标记物的完整性.

研究的目的:

开发和验证一种用于评估外部因素对指甲药物稳定性影响的新方法.
通过微细分分析评估各种手和指甲护理产品对指甲样本中药物度的影响.

主要方法:

准备含有从参与者获得的已知药物度的参考钉子.
微细分分析包括切割指甲,用护理产品处理一半,洗,每0.5毫米间隔细分,并提取.
使用液体染色学-并联质谱法 (LC-MS/MS) 量化药物分析物,以比较经过处理和未经处理的指甲片段.

主要成果:

在用美甲和凝指甲产品治疗后,药物度略有下降.
富含水的产品 (手肥,奶油) 与富含油的产品 (指甲油,无除) 相比,导致分析物的度较低.

结论:

开发的微细分分析方法有效评估外部产品对指甲药物稳定性的影响.
这种方法对法医调查非常有价值,特别是在评估来自挑战性环境条件或非自然死亡的指甲中药物的存在时.

关键词:

毒品毒品毒品是一种药物.液体色谱/双重质谱测量液体色谱/双重质谱微细分分析是微细分分析.钉钉钉的钉子钉钉的钉子.指甲护理指甲护理指甲护理

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